This article details the colorful ownership and uses of the Willey House, after its creation by the founder of the first University of California.

Notables: Samuel Hopkins Willey, Henry Willey, Peoples Saving Bank, Mary Weldon Sinnott Willey / Mary Willey / Molly Willey, Sarah Weldon Gamble / Sarah Gamble, Quincy Hally Seminary, Van Ness Seminary, Miss Hamlin's School for Girls, George W Cooper, Sisters of Charity, Holy Cross School, Gwendolyn Niemeyer